Avastin (bevacizumab) 16ml of 400mg/16ml

$1,704.41 $741.85



Avastin (bevacizumab) 16ml of 400mg/16ml

Avastin (bevacizumab) 16ml of 400mg/16ml is a monoclonal antibody. It is used to treat cervical cancer, colorectal cancer, glioblastoma multiforme, non-small cell lung cancer (NSCLC), ovarian cancer, and renal cell cancer. Indications and Usage, Recurrent Glioblastoma Dosage and Administration, Recurrent Glioblastoma. Warnings and Precautions, Congestive Heart Failure.


Avastin is a vascular endothelial growth factor directed antibody indicated for the treatment of:

• Metastatic colorectal cancer, in combination with intravenous 5-fluorouracil-based chemotherapy for first- or second-line treatment.
• Metastatic colorectal cancer, in combination with fluoropyrimidineirinotecan- or fluoropyrimidine-oxaliplatin-based chemotherapy for second-line treatment in patients who have progressed on a first-line Avastin-containing regimen.


Do not administer Avastin for 28 days following major surgery and until surgical wound is fully healed.

• 5 mg/kg every 2 weeks with bolus-IFL
• 10 mg/kg every 2 weeks with FOLFOX4
• 5 mg/ kg every 2 weeks or 7.5 mg/kg every 3 weeks with fluoropyrimidine-irinotecan- or fluoropyrimidine-oxaliplatin-based chemotherapy after progression on a first-line Avastin containing regimen.


• Perforation or Fistula: Discontinue for tracheoesophageal fistula, grade 4 fistula, or necrotizing fasciitis. (5.1)
• Arterial Thromboembolic Events (ATE): Discontinue for severe ATE.
• Venous Thromboembolic Events (VTE): Discontinue for Grade 4 VTE.
• Hypertension: Monitor blood pressure and treat hypertension. Withhold if not medically controlled; resume once controlled. Discontinue for hypertensive crisis or hypertensive encephalopathy.
• Posterior Reversible Encephalopathy Syndrome (PRES): Discontinue.
• Renal Injury and Proteinuria: Monitor urine protein. Discontinue for nephrotic syndrome. Withhold until less than 2 grams of protein in urine.
• Infusion Reactions: Decrease rate for infusion reactions. Discontinue for severe infusion reactions and administer medical therapy.
• Embryo-fetal Toxicity: Advise females of potential risk to fetus and need or use of effective contraception.
• Ovarian Failure: Advise females of the potential risk.
• Congestive Heart Failure (CHF): Discontinue if CHF.


Most common adverse reactions incidence (incidence > 10%) are epistaxis, headache, hypertension, rhinitis, proteinuria, taste alteration, dry skin, rectal hemorrhage, lacrimation disorder, back pain and exfoliative dermatitis.


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