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fentanyl durogesic 100 mcg/hr 3 boxes ( 5 transdermal patch/1 box)

$105.70$307.45

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SKU: 3 boxes 105.70$ ( 5 transdermal patch/1 box) Categories: ,

Description

fentanyl durogesic 100 mcg/hr 3 boxes ( 5 transdermal patch/1 box)

fentanyl durogesic 100 mcg/hr Injection, solution, as citrate [strength expressed as base]: 0.05 mg/mL (2 mL, 10 mL); 0.25 mg/ 5mL. Patch, transdermal, as base: 12 [delivers 12.5 mcg/hr]; 50 [delivers 50 mcg/hr]; 100 [delivers 100 mcg/hr].

Pain management: Adults:

(unlabeled use): Bolus at start of infusion: 1-2 mcg/kg or 25-100 mcg/dose; continuous infusion rate: 1-2 mcg/kg/hour or 25-200 mcg/hour.

Severe (unlabeled use): I.M, I.V.: 50-100 mcg/dose every 1-2 hours as needed; patients with prior opioid exposure may tolerate higher initial doses.

Patient-controlled analgesia (PCA) (unlabeled use):

Usual concentration: 10 mcg/mL.
Demand dose: Usual: 20 mcg; range: 10-50 mcg.
Lockout interval: 5-8 minutes.
Usual basal rate: ≤50 mcg/hour.

Availabilities

• injectable (50 ug/mL)
• transdermal patch
• sublingual
/ buccal tablet
• transmucosal film
• intranasal

 

Why Make a New Delivery Delivery System ?

• can give bigger doses
• can give more accurate doses
• aid mucosal adherence
• attenuate peak plasma concentration concentration
• can be patented

Interesting fact # 2

fentanyl: fentanyl: LD50 for monkeys monkeys = 0.03 mg/kg
(ie 600 ug of fentanyl will kill 50% of 20 kg monkeys)
LD50 for rats is 2 3. mg/kg iv, 1 0. mg/kg im

Fentanyl Fentanyl in (previous) (previous) Real Life

SC administration administration of 200ug fentanyl fentanyl
• Tmax – median 15 minutes (range 10‐30)
• Cmax – median 0 55 . ng/mL (range 0 28 . ‐0 87) .
• terminal ½ life = 10 hours (5.48 – 16.37h)
c/w: T½ 2.1 hours for morphine sc, 1.6 im
Tmax for im morphine = 20‐21 min
Tmax for sc morphine = 15‐16 min

Before you start using this medication, ask your doctor or pharmacist if you should stop or change how you use your other opioid medication(s). It may take up to 24 hours before you have pain relief from fentanyl patches. Other pain relievers (such as acetaminophen, ibuprofen) may also be prescribed. Ask your doctor or pharmacist about using fentanyl safely with other drugs.

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