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fentanyl durogesic 50 mcg /hr 5 boxes

$90.13$165.20

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SKU: 5 boxes 90.13$ ( 5 transdermal patch/1 box) Categories: ,

Description

fentanyl durogesic 50 mcg/hr 3 boxes ( 5 transdermal patch/1 box)

fentanyl durogesic 50 mcg/hr Injection, solution, as citrate [strength expressed as base]: 0.05 mg/mL (2 mL, 10 mL); 0.25 mg/ 5mL. Patch, transdermal, as base: 12 [delivers 12.5 mcg/hr]; 50 [delivers 50 mcg/hr]; 100 [delivers 100 mcg/hr].

Pain management: Adults:

(unlabeled use): Bolus at start of infusion: 1-2 mcg/kg or 25-100 mcg/dose; continuous infusion rate: 1-2 mcg/kg/hour or 25-200 mcg/hour.

Severe (unlabeled use): I.M, I.V.: 50-100 mcg/dose every 1-2 hours as needed; patients with prior opioid exposure may tolerate higher initial doses.

Patient-controlled analgesia (PCA) (unlabeled use):

Usual concentration: 10 mcg/mL.
Demand dose: Usual: 20 mcg; range: 10-50 mcg.
Lockout interval: 5-8 minutes.
Usual basal rate: ≤50 mcg/hour.

Availabilities

• injectable (50 ug/mL)
• transdermal patch
• sublingual
/ buccal tablet
• transmucosal film
• intranasal

 

Why Make a New Delivery Delivery System ?

• can give bigger doses
• can give more accurate doses
• aid mucosal adherence
• attenuate peak plasma concentration concentration
• can be patented

Interesting fact # 2

fentanyl: fentanyl: LD50 for monkeys monkeys = 0.03 mg/kg
(ie 600 ug of fentanyl will kill 50% of 20 kg monkeys)
LD50 for rats is 2 3. mg/kg iv, 1 0. mg/kg im

Fentanyl Fentanyl in (previous) (previous) Real Life

SC administration administration of 200ug fentanyl fentanyl
• Tmax – median 15 minutes (range 10‐30)
• Cmax – median 0 55 . ng/mL (range 0 28 . ‐0 87) .
• terminal ½ life = 10 hours (5.48 – 16.37h)
c/w: T½ 2.1 hours for morphine sc, 1.6 im
Tmax for im morphine = 20‐21 min
Tmax for sc morphine = 15‐16 min

Uses

This medication is used to help relieve severe ongoing pain (such as due to cancer). Fentanyl belongs to a class of drugs known as opioid (narcotic) analgesics. It works in the brain to change how your body feels and responds to pain.

Do not use the patch form of fentanyl to relieve pain that is mild or that will go away in a few days. This medication is not for occasional (“as needed”) use.

Additional information

Quantity

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